PEXEVA vs PROZAC WEEKLY

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. PEXEVA and PROZAC WEEKLY are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PEXEVA	PROZAC WEEKLY
Rating	New	New
Pharmacy pays	~$2.84 /30	$0.05 /mL
Type	RX	RX
Active ingredient	PAROXETINE MESYLATE	FLUOXETINE HYDROCHLORIDE
Manufacturer	Sebela Ireland Ltd	Lilly
Dosage forms	Tablet	Capsule, Oral pellets
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	None	None
Half-life	about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)	about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use
Treats	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder	Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

pexeva prozac weekly

Rating

New

Pharmacy pays

~$2.84 /30

$0.05 /mL

Type

Active ingredient

PAROXETINE MESYLATE

FLUOXETINE HYDROCHLORIDE

Manufacturer

Sebela Ireland Ltd

Lilly

Dosage forms

Tablet

Capsule, Oral pellets

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Half-life

about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)

about 1 to 3 days (roughly 24-72 hours) after a single dose, lengthening to about 4 to 6 days with ongoing daily use

Treats

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

Bulimia, Major Depressive Disorder, Obsessive-Compulsive Disorder

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Frequently asked questions

What is the difference between Pexeva and Prozac Weekly?

Pexeva contains Paroxetine Mesylate, while Prozac Weekly contains Fluoxetine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.