PERTOFRANE vs PRESAMINE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. PERTOFRANE and PRESAMINE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PERTOFRANE	PRESAMINE
Rating	70/100	70/100
Pharmacy pays	~$8.39 /30	~$2.54 /30
Type	RX	RX
Active ingredient	DESIPRAMINE HYDROCHLORIDE	IMIPRAMINE HYDROCHLORIDE
Manufacturer	Sanofi Aventis US	Sanofi Aventis US
Dosage forms	Capsule	Tablet
Drug class	Tricyclic Antidepressant	Tricyclic Antidepressant
Boxed warning	None	None
Treats	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

pertofrane presamine

Rating

70/100

Pharmacy pays

~$8.39 /30

~$2.54 /30

Type

Active ingredient

DESIPRAMINE HYDROCHLORIDE

IMIPRAMINE HYDROCHLORIDE

Manufacturer

Sanofi Aventis US

Dosage forms

Capsule

Tablet

Drug class

Tricyclic Antidepressant

Boxed warning

None

Treats

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Pain

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Enuresis

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Frequently asked questions

Which is better-rated, Pertofrane or Presamine?

Pertofrane and Presamine are tied at 3.5 out of 5 by our independent rating.

Which is cheaper, Pertofrane or Presamine?

Presamine costs pharmacies less to acquire — about $2.54 vs $8.39 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Pertofrane and Presamine?

Pertofrane contains Desipramine Hydrochloride, while Presamine contains Imipramine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.