PEPCID AC vs ZANTAC 300

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 13, 2026·How we rate

Attribute	PEPCID AC	ZANTAC 300
Rating	70/100	70/100
Pharmacy pays	~$1.54 /30	—
Type	OTC	RX
Active ingredient	FAMOTIDINE	RANITIDINE HYDROCHLORIDE
Manufacturer	Kenvue Brands	Glaxosmithkline
Dosage forms	Tablet	Capsule, Tablet
Drug class	Histamine-2 Receptor Antagonist	—
Boxed warning	None	None
Half-life	2.5 to 3.5 hours	about 2.5 to 3 hours
Treats	Duodenal Ulcer, Dyspepsia, Peptic Esophagitis	Duodenal Ulcer, Peptic Esophagitis, Gastroesophageal Reflux

pepcid ac zantac 300

Rating

70/100

Pharmacy pays

~$1.54 /30

—

Type

OTC

Active ingredient

FAMOTIDINE

RANITIDINE HYDROCHLORIDE

Manufacturer

Kenvue Brands

Glaxosmithkline

Dosage forms

Tablet

Capsule, Tablet

Drug class

Histamine-2 Receptor Antagonist

—

Boxed warning

None

Half-life

2.5 to 3.5 hours

about 2.5 to 3 hours

Treats

Duodenal Ulcer, Dyspepsia, Peptic Esophagitis

Duodenal Ulcer, Peptic Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Pepcid Ac or Zantac 300?

Pepcid Ac and Zantac 300 are tied at 3.5 out of 5 by our independent rating.

What is the difference between Pepcid Ac and Zantac 300?

Pepcid Ac contains Famotidine, while Zantac 300 contains Ranitidine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.