PAROXETINE HYDROCHLORIDE vs TRAZODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. PAROXETINE HYDROCHLORIDE and TRAZODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	PAROXETINE HYDROCHLORIDE	TRAZODONE HYDROCHLORIDE
Rating	66/100	New
Pharmacy pays	~$2.84 /30	~$1.52 /30
Type	RX	RX
Active ingredient	PAROXETINE HYDROCHLORIDE	TRAZODONE HYDROCHLORIDE
Manufacturer	Apotex	Crossmedika Sa
Dosage forms	Suspension, Tablet, extended release	Tablet
Drug class	Serotonin Reuptake Inhibitor	Serotonin Reuptake Inhibitor
Boxed warning	None	None
Half-life	about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)	about 7 hours (roughly 5 to 9 hours for the slower elimination phase)
Treats	Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder	Depressive Disorder, Sleep Initiation and Maintenance Disorders

paroxetine hydrochloride trazodone hydrochloride

Rating

66/100

New

Pharmacy pays

~$2.84 /30

~$1.52 /30

Type

Active ingredient

PAROXETINE HYDROCHLORIDE

TRAZODONE HYDROCHLORIDE

Manufacturer

Apotex

Crossmedika Sa

Dosage forms

Suspension, Tablet, extended release

Tablet

Drug class

Serotonin Reuptake Inhibitor

Boxed warning

None

Half-life

about 21 hours on average (the label reports a mean of approximately 21 hours, with 32% variability between people)

about 7 hours (roughly 5 to 9 hours for the slower elimination phase)

Treats

Feeding and Eating Disorders, Depressive Disorder, Obsessive-Compulsive Disorder

Depressive Disorder, Sleep Initiation and Maintenance Disorders

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Frequently asked questions

Which is cheaper, Paroxetine Hydrochloride or Trazodone Hydrochloride?

Trazodone Hydrochloride costs pharmacies less to acquire — about $1.52 vs $2.84 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Paroxetine Hydrochloride and Trazodone Hydrochloride?

Paroxetine Hydrochloride contains Paroxetine Hydrochloride, while Trazodone Hydrochloride contains Trazodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.