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OXYCODONE HYDROCHLORIDE vs PALLADONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. OXYCODONE HYDROCHLORIDE and PALLADONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

oxycodone hydrochloridepalladone

Rating

70/100
New

Pharmacy pays

$0.08 /mL
$0.57 /mL

Type

RX
RX

Active ingredient

OXYCODONE HYDROCHLORIDE
HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Vistapharm LLC
Purdue Pharma LP

Dosage forms

Solution, Tablet, Tablet, extended release
Capsule, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 3.5 to 4 hours
about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Postoperative Pain
Cough, Postoperative Pain

Frequently asked questions

Which is cheaper, Oxycodone Hydrochloride or Palladone?

Oxycodone Hydrochloride costs pharmacies less to acquire — about $0.08 vs $0.57 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Oxycodone Hydrochloride and Palladone?

Oxycodone Hydrochloride contains Oxycodone Hydrochloride, while Palladone contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.