ORACEA vs PERIOSTAT

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. ORACEA and PERIOSTAT are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ORACEA	PERIOSTAT
Rating	New	New
Pharmacy pays	$0.12 /mL	$0.12 /mL
Type	RX	RX
Active ingredient	DOXYCYCLINE	DOXYCYCLINE HYCLATE
Manufacturer	Galderma Labs LP	Collagenex
Dosage forms	Capsule	Capsule, Tablet
Drug class	Tetracycline-Class Drug	Tetracycline-Class Drug
Boxed warning	None	None
Half-life	about 16 to 22 hours in healthy adults	about 16 to 22 hours in healthy adults
Treats	Anthrax, Campylobacter Infections, Cholera	Anthrax, Campylobacter Infections, Cholera

oracea periostat

Rating

New

Pharmacy pays

$0.12 /mL

Type

Active ingredient

DOXYCYCLINE

DOXYCYCLINE HYCLATE

Manufacturer

Galderma Labs LP

Collagenex

Dosage forms

Capsule

Capsule, Tablet

Drug class

Tetracycline-Class Drug

Boxed warning

None

Half-life

about 16 to 22 hours in healthy adults

Treats

Anthrax, Campylobacter Infections, Cholera

Frequently asked questions

Which is cheaper, Oracea or Periostat?

Pharmacies pay about the same to acquire either one — roughly $0.12 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Oracea and Periostat?

Oracea contains Doxycycline, while Periostat contains Doxycycline Hyclate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.