OPANA vs PALLADONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. OPANA and PALLADONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OPANA	PALLADONE
Rating	72/100	New
Pharmacy pays	~$36.74 /30	$0.57 /mL
Type	RX	RX
Active ingredient	OXYMORPHONE HYDROCHLORIDE	HYDROMORPHONE HYDROCHLORIDE
Manufacturer	Endo Pharms	Purdue Pharma LP
Dosage forms	Tablet, Injectable	Capsule, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
Treats	Pain	Cough, Postoperative Pain

opana palladone

Rating

72/100

New

Pharmacy pays

~$36.74 /30

$0.57 /mL

Type

Active ingredient

OXYMORPHONE HYDROCHLORIDE

HYDROMORPHONE HYDROCHLORIDE

Manufacturer

Endo Pharms

Purdue Pharma LP

Dosage forms

Tablet, Injectable

Capsule, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Pain

Cough, Postoperative Pain

Frequently asked questions

What is the difference between Opana and Palladone?

Opana contains Oxymorphone Hydrochloride, while Palladone contains Hydromorphone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.