OPANA vs OPANA ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Attribute	OPANA	OPANA ER
Rating	72/100	New
Pharmacy pays	~$36.74 /30	~$36.74 /30
Type	RX	RX
Active ingredient	OXYMORPHONE HYDROCHLORIDE	OXYMORPHONE HYDROCHLORIDE
Manufacturer	Endo Pharms	Endo Operations
Dosage forms	Tablet, Injectable	Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Treats	Pain	Pain

opana opana er

Rating

72/100

New

Pharmacy pays

~$36.74 /30

Type

Active ingredient

OXYMORPHONE HYDROCHLORIDE

Manufacturer

Endo Pharms

Endo Operations

Dosage forms

Tablet, Injectable

Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Treats

Pain

Frequently asked questions

Which is cheaper, Opana or Opana ER?

Pharmacies pay about the same to acquire either one — roughly $36.74 for a 30-count supply, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Opana and Opana ER?

Both Opana and Opana ER share the active ingredient Oxymorphone Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.