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opana er

Opana ER (Oxymorphone Hydrochloride) is an opioid agonist used to treat Pain.

Oxymorphone Hydrochloride · by Endo Operations

Not yet rated· sourced from the FDA label
Rated against independent regulatory sources·Last updated June 7, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass

Key facts

Active ingredient
Oxymorphone Hydrochloride
Drug class
Opioid Agonist
Form
Tablet, extended release
Strength
Oxymorphone Hydrochloride 10MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Oxymorphone Hydrochloride 15MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Oxymorphone Hydrochloride 20MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Oxymorphone Hydrochloride 30MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Oxymorphone Hydrochloride 40MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Oxymorphone Hydrochloride 5MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons** · Oxymorphone Hydrochloride 7.5MG **Federal Register Determination That Product was not Discontinued or Withdrawn for Safety or Effectiveness reasons**
Type
Prescription (Rx)
Brand or generic
Brand-name
May treat
pain
Manufacturer
Endo Operations
What the pharmacy pays
~$36.74 for 30 — not your price
FDA application
NDA021610
Availability
Discontinued (per FDA)

Drug class

How this class works, per Mu Receptors - StatPearls - NCBI Bookshelf.

May treat (source: NIH RxClass)

See how Opana ER ranks — best-rated opioid agonist for:

Dosage forms

Tablet, extended release

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Opana ER treat?
Opana ER (Oxymorphone Hydrochloride) may be used to treat pain, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How does Opana ER work?
Opana ER is a opioid agonist. Opioid agonists bind opioid receptors (mainly mu receptors) on nerves in the brain and spinal cord, dampening the release of pain-signaling chemicals so fewer pain messages reach the brain, which relieves moderate to severe pain.
How much does Opana ER cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $36.74 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Opana ER?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Opana ER. To pay less, ask your prescriber or pharmacist whether a generic equivalent exists, check the manufacturer's copay/savings card and patient-assistance program, and compare a pharmacy discount card against your insurance copay. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Opana ER?
Opana ER is marketed by Endo Operations. You can see Endo Operations's full profile, rating, and other products on pharmaranks.
Is Opana ER a brand-name or generic drug?
Opana ER is a brand-name product with the active ingredient Oxymorphone Hydrochloride.
Is Opana ER available over the counter?
No. Opana ER is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Opana ER come in?
Opana ER is currently marketed as tablet, extended release, per the FDA's National Drug Code Directory.
What class of drug is Opana ER?
Opana ER is classified as opioid agonist, per the FDA's Established Pharmacologic Class.
Is Opana ER FDA-registered?
Opana ER is on record with the U.S. FDA under application number NDA021610. You can verify this on its official FDA label.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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