OPANA ER vs ROXICODONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 5, 2026·How we rate

Possible drug interaction. OPANA ER and ROXICODONE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OPANA ER	ROXICODONE
Rating	New	70/100
Pharmacy pays	~$36.74 /30	$0.08 /mL
Type	RX	RX
Active ingredient	OXYMORPHONE HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Endo Operations	Roxane
Dosage forms	Tablet, extended release	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 3.5 to 4 hours
Treats	Pain	Postoperative Pain

opana er roxicodone

Rating

New

70/100

Pharmacy pays

~$36.74 /30

$0.08 /mL

Type

Active ingredient

OXYMORPHONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Endo Operations

Roxane

Dosage forms

Tablet, extended release

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 3.5 to 4 hours

Treats

Pain

Postoperative Pain

Frequently asked questions

What is the difference between Opana ER and Roxicodone?

Opana ER contains Oxymorphone Hydrochloride, while Roxicodone contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.