OPANA ER vs OXYCODONE HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 15, 2026·How we rate

Possible drug interaction. OPANA ER and OXYCODONE HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	OPANA ER	OXYCODONE HYDROCHLORIDE
Rating	New	70/100
Pharmacy pays	~$36.74 /30	$0.08 /mL
Type	RX	RX
Active ingredient	OXYMORPHONE HYDROCHLORIDE	OXYCODONE HYDROCHLORIDE
Manufacturer	Endo Operations	Vistapharm LLC
Dosage forms	Tablet, extended release	Solution, Tablet, Tablet, extended release
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 3.5 to 4 hours
Treats	Pain	Postoperative Pain

opana er oxycodone hydrochloride

Rating

New

70/100

Pharmacy pays

~$36.74 /30

$0.08 /mL

Type

Active ingredient

OXYMORPHONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE

Manufacturer

Endo Operations

Vistapharm LLC

Dosage forms

Tablet, extended release

Solution, Tablet, Tablet, extended release

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 3.5 to 4 hours

Treats

Pain

Postoperative Pain

Frequently asked questions

What is the difference between Opana ER and Oxycodone Hydrochloride?

Opana ER contains Oxymorphone Hydrochloride, while Oxycodone Hydrochloride contains Oxycodone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.