ONTRALFY vs TENEX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. ONTRALFY and TENEX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ONTRALFY	TENEX
Rating	New	New
Pharmacy pays	~$1.00 /30	~$5.26 /30
Type	RX	RX
Active ingredient	TIZANIDINE HYDROCHLORIDE	GUANFACINE HYDROCHLORIDE
Manufacturer	Fidelity Biopharma	Promius Pharma
Dosage forms	Solution	Tablet
Drug class	Central Alpha-2 Adrenergic Agonist	Central Alpha-2 Adrenergic Agonist
Boxed warning	None	None
Half-life	about 2.5 hours	—
Treats	Muscle Cramp, Muscle Rigidity, Muscle Spasticity	Attention Deficit Disorder with Hyperactivity, Hypertension

ontralfy tenex

Rating

New

Pharmacy pays

~$1.00 /30

~$5.26 /30

Type

Active ingredient

TIZANIDINE HYDROCHLORIDE

GUANFACINE HYDROCHLORIDE

Manufacturer

Fidelity Biopharma

Promius Pharma

Dosage forms

Solution

Tablet

Drug class

Central Alpha-2 Adrenergic Agonist

Boxed warning

None

Half-life

about 2.5 hours

—

Treats

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Attention Deficit Disorder with Hyperactivity, Hypertension

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Frequently asked questions

Which is cheaper, Ontralfy or Tenex?

Ontralfy costs pharmacies less to acquire — about $1.00 vs $5.26 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Ontralfy and Tenex?

Ontralfy contains Tizanidine Hydrochloride, while Tenex contains Guanfacine Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.