ONSOLIS vs ULTRAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ONSOLIS and ULTRAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ONSOLIS	ULTRAM
Rating	New	70/100
Pharmacy pays	$9.51 /mL	~$0.72 /30
Type	RX	RX
Active ingredient	FENTANYL CITRATE	TRAMADOL HYDROCHLORIDE
Manufacturer	Adalvo	Janssen Pharms
Dosage forms	Film	Tablet
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	None	None
Half-life	—	about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)
Treats	Pain	Pain

onsolis ultram

Rating

New

70/100

Pharmacy pays

$9.51 /mL

~$0.72 /30

Type

Active ingredient

FENTANYL CITRATE

TRAMADOL HYDROCHLORIDE

Manufacturer

Adalvo

Janssen Pharms

Dosage forms

Film

Tablet

Drug class

Opioid Agonist

Boxed warning

None

Half-life

—

about 6 hours (mean terminal elimination half-life of tramadol in healthy adults)

Treats

Pain

Frequently asked questions

What is the difference between Onsolis and Ultram?

Onsolis contains Fentanyl Citrate, while Ultram contains Tramadol Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.