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OMEPRAZOLE vs PRILOSEC OTC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Rating

New
70/100

Pharmacy pays

~$1.52 /30

Type

RX
OTC

Active ingredient

OMEPRAZOLE
OMEPRAZOLE MAGNESIUM

Dosage forms

Capsule, Capsule, delayed release, Oral pellets, Tablet, delayed release, Tablet, orally disintegrating, delayed release
Tablet, delayed release

Drug class

Proton Pump Inhibitor
Proton Pump Inhibitor

Boxed warning

None
None

Half-life

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux
Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

Get prilosec otchigher-rated option

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Get treatment online

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Where to buy

Buy over-the-counter from trusted retailers.

Frequently asked questions

What is the difference between Omeprazole and Prilosec OTC?

Omeprazole contains Omeprazole, while Prilosec OTC contains Omeprazole Magnesium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.