OMEPRAZOLE MAGNESIUM vs PRILOSEC OTC

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Attribute	OMEPRAZOLE MAGNESIUM	PRILOSEC OTC
Rating	68/100	70/100
Pharmacy pays	—	—
Type	RX	OTC
Active ingredient	OMEPRAZOLE MAGNESIUM	OMEPRAZOLE MAGNESIUM
Manufacturer	Aurobindo Pharma Ltd	Astrazeneca
Dosage forms	Capsule, delayed release	Tablet, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults	about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

omeprazole magnesium prilosec otc

Rating

68/100

70/100

Pharmacy pays

—

Type

OTC

Active ingredient

OMEPRAZOLE MAGNESIUM

Manufacturer

Aurobindo Pharma Ltd

Astrazeneca

Dosage forms

Capsule, delayed release

Tablet, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

about 0.5 to 1 hour (roughly half an hour to an hour) in healthy adults

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Omeprazole Magnesium or Prilosec OTC?

By our independent rating, Prilosec OTC scores higher — 3.5 vs 3.4 out of 5 for Omeprazole Magnesium. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Omeprazole Magnesium and Prilosec OTC?

Both Omeprazole Magnesium and Prilosec OTC share the active ingredient Omeprazole Magnesium, but Omeprazole Magnesium is sold as RX and Prilosec OTC as OTC.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.