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NUMORPHAN vs SUBSYS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. NUMORPHAN and SUBSYS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
New

Pharmacy pays

~$36.74 /30
$9.51 /mL

Type

RX
RX

Active ingredient

OXYMORPHONE HYDROCHLORIDE
FENTANYL

Dosage forms

Suppository
Spray/Inhaler

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Treats

Pain
Pain

Frequently asked questions

What is the difference between Numorphan and Subsys?

Numorphan contains Oxymorphone Hydrochloride, while Subsys contains Fentanyl — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.