NEXIUM vs PREVACID 24 HR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Attribute	NEXIUM	PREVACID 24 HR
Rating	70/100	64/100
Pharmacy pays	—	~$5.12 /30
Type	RX	OTC
Active ingredient	ESOMEPRAZOLE MAGNESIUM	LANSOPRAZOLE
Manufacturer	Astrazeneca	Perrigo
Dosage forms	Capsule, delayed release, Powder, delayed release	Capsule, delayed release
Drug class	Proton Pump Inhibitor	Proton Pump Inhibitor
Boxed warning	None	None
Half-life	—	about 1.5 hours (mean, ±1.0) in healthy adults — the label states the plasma elimination half-life is less than two hours
Treats	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux	Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

nexium prevacid 24 hr

Rating

70/100

64/100

Pharmacy pays

—

~$5.12 /30

Type

OTC

Active ingredient

ESOMEPRAZOLE MAGNESIUM

LANSOPRAZOLE

Manufacturer

Astrazeneca

Perrigo

Dosage forms

Capsule, delayed release, Powder, delayed release

Capsule, delayed release

Drug class

Proton Pump Inhibitor

Boxed warning

None

Half-life

—

about 1.5 hours (mean, ±1.0) in healthy adults — the label states the plasma elimination half-life is less than two hours

Treats

Duodenal Ulcer, Esophagitis, Gastroesophageal Reflux

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Frequently asked questions

Which is better-rated, Nexium or Prevacid 24 Hr?

By our independent rating, Nexium scores higher — 3.5 vs 3.2 out of 5 for Prevacid 24 Hr. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Nexium and Prevacid 24 Hr?

Nexium contains Esomeprazole Magnesium, while Prevacid 24 Hr contains Lansoprazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.