MYSOLINE vs PERCODAN-DEMI

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 6, 2026·How we rate

Possible drug interaction. MYSOLINE and PERCODAN-DEMI are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MYSOLINE	PERCODAN-DEMI
Rating	74/100	New
Pharmacy pays	~$2.89 /30	~$0.78 /30
Type	RX	RX
Active ingredient	PRIMIDONE	ASPIRIN AND OXYCODONE HYDROCHLORIDE AND OXYCODONE TEREPHTHALATE
Manufacturer	Valeant Pharm Intl	Endo Operations
Dosage forms	Tablet	Tablet
Drug class	Anti-Epileptic Agent	—
Boxed warning	None	None
Half-life	—	about 3.5 to 4 hours
Treats	Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor	—

mysoline percodan-demi

Rating

74/100

New

Pharmacy pays

~$2.89 /30

~$0.78 /30

Type

Active ingredient

PRIMIDONE

ASPIRIN AND OXYCODONE HYDROCHLORIDE AND OXYCODONE TEREPHTHALATE

Manufacturer

Valeant Pharm Intl

Endo Operations

Dosage forms

Tablet

Drug class

Anti-Epileptic Agent

—

Boxed warning

None

Half-life

—

about 3.5 to 4 hours

Treats

Partial Epilepsies, Tonic-Clonic Epilepsy, Tremor

—

Frequently asked questions

Which is cheaper, Mysoline or Percodan-Demi?

Percodan-Demi costs pharmacies less to acquire — about $0.78 vs $2.89 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mysoline and Percodan-Demi?

Mysoline contains Primidone, while Percodan-Demi contains Aspirin and Oxycodone Hydrochloride and Oxycodone Terephthalate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.