MONISTAT vs ONMEL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. MONISTAT and ONMEL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MONISTAT	ONMEL
Rating	70/100	New
Pharmacy pays	$0.12 /g	$0.84 /mL
Type	RX	RX
Active ingredient	MICONAZOLE	ITRACONAZOLE
Manufacturer	Janssen Pharms	Sebela Ireland Ltd
Dosage forms	Injectable	Tablet
Drug class	Azole Antifungal	Azole Antifungal
Boxed warning	None	None
Half-life	—	Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.
Treats	Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis	Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

monistat onmel

Rating

70/100

New

Pharmacy pays

$0.12 /g

$0.84 /mL

Type

Active ingredient

MICONAZOLE

ITRACONAZOLE

Manufacturer

Janssen Pharms

Sebela Ireland Ltd

Dosage forms

Injectable

Tablet

Drug class

Azole Antifungal

Boxed warning

None

Half-life

—

Terminal (elimination) half-life is about 16 to 28 hours after a single dose, rising to roughly 34 to 42 hours with repeated (steady-state) dosing.

Treats

Aspergillosis, Cutaneous Candidiasis, Vulvovaginal Candidiasis

Aspergillosis, Blastomycosis, Chronic Mucocutaneous Candidiasis

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Frequently asked questions

What is the difference between Monistat and Onmel?

Monistat contains Miconazole, while Onmel contains Itraconazole — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.