MEXITIL vs RYTHMOL

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. MEXITIL and RYTHMOL are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MEXITIL	RYTHMOL
Rating	72/100	70/100
Pharmacy pays	~$8.44 /30	~$10.51 /30
Type	RX	RX
Active ingredient	MEXILETINE HYDROCHLORIDE	PROPAFENONE HYDROCHLORIDE
Manufacturer	Boehringer Ingelheim	Glaxosmithkline
Dosage forms	Capsule	Tablet
Drug class	Antiarrhythmic	Antiarrhythmic
Boxed warning	None	None
Half-life	—	about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers
Treats	Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes	Atrial Fibrillation, Supraventricular Tachycardia

mexitil rythmol

Rating

72/100

70/100

Pharmacy pays

~$8.44 /30

~$10.51 /30

Type

Active ingredient

MEXILETINE HYDROCHLORIDE

PROPAFENONE HYDROCHLORIDE

Manufacturer

Boehringer Ingelheim

Glaxosmithkline

Dosage forms

Capsule

Tablet

Drug class

Antiarrhythmic

Boxed warning

None

Half-life

—

about 2 to 10 hours (immediate-release) in the ~90% of adults who are extensive CYP2D6 metabolizers

Treats

Diabetic Neuropathies, Ventricular Fibrillation, Ventricular Premature Complexes

Atrial Fibrillation, Supraventricular Tachycardia

Frequently asked questions

Which is better-rated, Mexitil or Rythmol?

By our independent rating, Mexitil scores higher — 3.6 vs 3.5 out of 5 for Rythmol. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Mexitil or Rythmol?

Mexitil costs pharmacies less to acquire — about $8.44 vs $10.51 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Mexitil and Rythmol?

Mexitil contains Mexiletine Hydrochloride, while Rythmol contains Propafenone Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.