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METHADONE HYDROCHLORIDE vs ONSOLIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. METHADONE HYDROCHLORIDE and ONSOLIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

72/100
New

Pharmacy pays

$0.18 /mL
$9.51 /mL

Type

RX
RX

Active ingredient

METHADONE HYDROCHLORIDE
FENTANYL CITRATE

Manufacturer

Dosage forms

Injectable, Solution, Tablet
Film

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

Half-life

about 8 to 59 hours (terminal/elimination half-life; a very wide range)

Treats

Opioid-Related Disorders, Intractable Pain
Pain

Frequently asked questions

Which is cheaper, Methadone Hydrochloride or Onsolis?

Methadone Hydrochloride costs pharmacies less to acquire — about $0.18 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Methadone Hydrochloride and Onsolis?

Methadone Hydrochloride contains Methadone Hydrochloride, while Onsolis contains Fentanyl Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.