MEKINIST vs TAGRISSO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. MEKINIST and TAGRISSO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MEKINIST	TAGRISSO
Rating	70/100	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	TRAMETINIB DIMETHYL SULFOXIDE	OSIMERTINIB MESYLATE
Manufacturer	Novartis	Astrazeneca
Dosage forms	Powder, Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Treats	Non-Small-Cell Lung Carcinoma, Melanoma	Non-Small-Cell Lung Carcinoma

mekinist tagrisso

Rating

70/100

Pharmacy pays

—

Type

Active ingredient

TRAMETINIB DIMETHYL SULFOXIDE

OSIMERTINIB MESYLATE

Manufacturer

Novartis

Astrazeneca

Dosage forms

Powder, Tablet

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Treats

Non-Small-Cell Lung Carcinoma, Melanoma

Non-Small-Cell Lung Carcinoma

Frequently asked questions

Which is better-rated, Mekinist or Tagrisso?

Mekinist and Tagrisso are tied at 3.5 out of 5 by our independent rating.

What is the difference between Mekinist and Tagrisso?

Mekinist contains Trametinib Dimethyl Sulfoxide, while Tagrisso contains Osimertinib Mesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.