MEGACE vs PLAN B

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. MEGACE and PLAN B are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	MEGACE	PLAN B
Rating	72/100	New
Pharmacy pays	~$7.14 /30	~$192.31 /30
Type	RX	RX
Active ingredient	MEGESTROL ACETATE	LEVONORGESTREL
Manufacturer	Bristol Myers Squibb	Fdn Consumer
Dosage forms	Tablet, Suspension	Tablet
Drug class	Progestin	Progestin
Boxed warning	None	None
Half-life	—	about 36 hours (36 ± 13 hours at steady state)
Treats	Anorexia, Breast Neoplasms, Cachexia	—

megace plan b

Rating

72/100

New

Pharmacy pays

~$7.14 /30

~$192.31 /30

Type

Active ingredient

MEGESTROL ACETATE

LEVONORGESTREL

Manufacturer

Bristol Myers Squibb

Fdn Consumer

Dosage forms

Tablet, Suspension

Tablet

Drug class

Progestin

Boxed warning

None

Half-life

—

about 36 hours (36 ± 13 hours at steady state)

Treats

Anorexia, Breast Neoplasms, Cachexia

—

Frequently asked questions

Which is cheaper, Megace or Plan B?

Megace costs pharmacies less to acquire — about $7.14 vs $192.31 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Megace and Plan B?

Megace contains Megestrol Acetate, while Plan B contains Levonorgestrel — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.