LURASIDONE HYDROCHLORIDE vs SAPHRIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. LURASIDONE HYDROCHLORIDE and SAPHRIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LURASIDONE HYDROCHLORIDE	SAPHRIS
Rating	New	70/100
Pharmacy pays	~$9.42 /30	~$73.98 /30
Type	RX	RX
Active ingredient	LURASIDONE HYDROCHLORIDE	ASENAPINE MALEATE
Manufacturer	Chartwell Rx	Abbvie
Dosage forms	Tablet	Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	about 18 hours (mean, %CV 7), measured after a 40 mg oral dose in adults	about 24 hours (terminal/elimination half-life)
Treats	Bipolar Disorder, Major Depressive Disorder, Schizophrenia	Bipolar Disorder, Schizophrenia

lurasidone hydrochloride saphris

Rating

New

70/100

Pharmacy pays

~$9.42 /30

~$73.98 /30

Type

Active ingredient

LURASIDONE HYDROCHLORIDE

ASENAPINE MALEATE

Manufacturer

Chartwell Rx

Abbvie

Dosage forms

Tablet

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

about 18 hours (mean, %CV 7), measured after a 40 mg oral dose in adults

about 24 hours (terminal/elimination half-life)

Treats

Bipolar Disorder, Major Depressive Disorder, Schizophrenia

Bipolar Disorder, Schizophrenia

Frequently asked questions

Which is cheaper, Lurasidone Hydrochloride or Saphris?

Lurasidone Hydrochloride costs pharmacies less to acquire — about $9.42 vs $73.98 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Lurasidone Hydrochloride and Saphris?

Lurasidone Hydrochloride contains Lurasidone Hydrochloride, while Saphris contains Asenapine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.