LORBRENA vs TAGRISSO

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. LORBRENA and TAGRISSO are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LORBRENA	TAGRISSO
Rating	64/100	70/100
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	LORLATINIB	OSIMERTINIB MESYLATE
Manufacturer	Pfizer	Astrazeneca
Dosage forms	Tablet	Tablet
Drug class	Kinase Inhibitor	Kinase Inhibitor
Boxed warning	None	None
Treats	—	Non-Small-Cell Lung Carcinoma

lorbrena tagrisso

Rating

64/100

70/100

Pharmacy pays

—

Type

Active ingredient

LORLATINIB

OSIMERTINIB MESYLATE

Manufacturer

Pfizer

Astrazeneca

Dosage forms

Tablet

Drug class

Kinase Inhibitor

Boxed warning

None

Treats

—

Non-Small-Cell Lung Carcinoma

Frequently asked questions

Which is better-rated, Lorbrena or Tagrisso?

By our independent rating, Tagrisso scores higher — 3.5 vs 3.2 out of 5 for Lorbrena. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Lorbrena and Tagrisso?

Lorbrena contains Lorlatinib, while Tagrisso contains Osimertinib Mesylate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.