LOPERAMIDE HYDROCHLORIDE vs ONSOLIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. LOPERAMIDE HYDROCHLORIDE and ONSOLIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LOPERAMIDE HYDROCHLORIDE	ONSOLIS
Rating	70/100	New
Pharmacy pays	$0.05 /mL	$9.51 /mL
Type	RX	RX
Active ingredient	LOPERAMIDE HYDROCHLORIDE	FENTANYL CITRATE
Manufacturer	Jubilant Cadista	Adalvo
Dosage forms	Capsule	Film
Drug class	Opioid Agonist	Opioid Agonist
Boxed warning	Boxed warning	None
Half-life	about 10.8 hours (range 9.1 to 14.4 hours)	—
Treats	Functional Colonic Diseases, Diarrhea, Bacillary Dysentery	Pain

loperamide hydrochloride onsolis

Rating

70/100

New

Pharmacy pays

$0.05 /mL

$9.51 /mL

Type

Active ingredient

LOPERAMIDE HYDROCHLORIDE

FENTANYL CITRATE

Manufacturer

Jubilant Cadista

Adalvo

Dosage forms

Capsule

Film

Drug class

Opioid Agonist

Boxed warning

None

Half-life

about 10.8 hours (range 9.1 to 14.4 hours)

—

Treats

Functional Colonic Diseases, Diarrhea, Bacillary Dysentery

Pain

Frequently asked questions

Which is cheaper, Loperamide Hydrochloride or Onsolis?

Loperamide Hydrochloride costs pharmacies less to acquire — about $0.05 vs $9.51 per ml, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Loperamide Hydrochloride and Onsolis?

Loperamide Hydrochloride contains Loperamide Hydrochloride, while Onsolis contains Fentanyl Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.