LODINE XL vs PIROXICAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. LODINE XL and PIROXICAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	LODINE XL	PIROXICAM
Rating	New	72/100
Pharmacy pays	~$22.58 /30	~$5.35 /30
Type	RX	RX
Active ingredient	ETODOLAC	PIROXICAM
Manufacturer	Wyeth Pharms Inc	Unichem
Dosage forms	Tablet, extended release	Capsule
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	Boxed warning
Half-life	about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)	—
Treats	Rheumatoid Arthritis, Osteoarthritis, Pain	Rheumatoid Arthritis, Inflammation, Osteoarthritis

lodine xl piroxicam

Rating

New

72/100

Pharmacy pays

~$22.58 /30

~$5.35 /30

Type

Active ingredient

ETODOLAC

PIROXICAM

Manufacturer

Wyeth Pharms Inc

Unichem

Dosage forms

Tablet, extended release

Capsule

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Boxed warning

Half-life

about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)

—

Treats

Rheumatoid Arthritis, Osteoarthritis, Pain

Rheumatoid Arthritis, Inflammation, Osteoarthritis

Frequently asked questions

Which is cheaper, Lodine XL or Piroxicam?

Piroxicam costs pharmacies less to acquire — about $5.35 vs $22.58 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Lodine XL and Piroxicam?

Lodine XL contains Etodolac, while Piroxicam contains Piroxicam — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.