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LIDOCAINE HYDROCHLORIDE vs XYLOCAINE 4% PRESERVATIVE FREE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate
lidocaine hydrochloridexylocaine 4% preservative free

Rating

60/100
68/100

Pharmacy pays

$0.24 /mL
$0.24 /mL

Type

RX
RX

Active ingredient

LIDOCAINE HYDROCHLORIDE
LIDOCAINE HYDROCHLORIDE

Manufacturer

Hospira
Fresenius Kabi USA

Dosage forms

Injectable, Solution, Topical, Jelly, Liquid, Spray/Inhaler
Injectable, Solution

Drug class

Amide Local Anesthetic
Amide Local Anesthetic

Boxed warning

None
None

Treats

Burns, Esophageal Diseases, Mouth Diseases
Burns, Esophageal Diseases, Mouth Diseases

Frequently asked questions

Which is better-rated, Lidocaine Hydrochloride or Xylocaine 4% Preservative Free?

By our independent rating, Xylocaine 4% Preservative Free scores higher — 3.4 vs 3.0 out of 5 for Lidocaine Hydrochloride. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Lidocaine Hydrochloride or Xylocaine 4% Preservative Free?

Pharmacies pay about the same to acquire either one — roughly $0.24 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Lidocaine Hydrochloride and Xylocaine 4% Preservative Free?

Both Lidocaine Hydrochloride and Xylocaine 4% Preservative Free share the active ingredient Lidocaine Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.