INVOKANA vs METFORMIN HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 10, 2026·How we rate

Possible drug interaction. INVOKANA and METFORMIN HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INVOKANA	METFORMIN HYDROCHLORIDE
Rating	72/100	72/100
Pharmacy pays	—	~$0.74 /30
Type	RX	RX
Active ingredient	CANAGLIFLOZIN	METFORMIN HYDROCHLORIDE
Manufacturer	Janssen Pharms	Granules
Dosage forms	Tablet	Solution, Tablet, Tablet, extended release
Drug class	Sodium-Glucose Cotransporter 2 Inhibitor	Biguanide
Boxed warning	None	None
Half-life	—	about 6.2 hours (plasma elimination half-life in adults with normal kidney function)
Treats	Type 2 Diabetes Mellitus	Type 2 Diabetes Mellitus

invokana metformin hydrochloride

Rating

72/100

Pharmacy pays

—

~$0.74 /30

Type

Active ingredient

CANAGLIFLOZIN

METFORMIN HYDROCHLORIDE

Manufacturer

Janssen Pharms

Granules

Dosage forms

Tablet

Solution, Tablet, Tablet, extended release

Drug class

Sodium-Glucose Cotransporter 2 Inhibitor

Biguanide

Boxed warning

None

Half-life

—

about 6.2 hours (plasma elimination half-life in adults with normal kidney function)

Treats

Type 2 Diabetes Mellitus

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Frequently asked questions

Which is better-rated, Invokana or Metformin Hydrochloride?

Invokana and Metformin Hydrochloride are tied at 3.6 out of 5 by our independent rating.

What is the difference between Invokana and Metformin Hydrochloride?

Invokana contains Canagliflozin, while Metformin Hydrochloride contains Metformin Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.