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metformin hydrochloride

Pharmaranks rates Metformin Hydrochloride 3.6/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Metformin Hydrochloride is a biguanide used to treat Type 2 Diabetes Mellitus.

Biguanide · by Granules

Generic of Glucophage

72/100Limited · 1 source

Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate
Verified againstopenFDANIH DailyMedRxClass
~$0.74 /30
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Key facts

Active ingredient
Metformin Hydrochloride
Drug class
Biguanide
Form
Solution, Tablet, Tablet, extended release
Strength
Metformin Hydrochloride 500MG
Type
Prescription (Rx)
Brand or generic
Generic
Manufacturer
Granules
Half-life
about 6.2 hours (plasma elimination half-life in adults with normal kidney function) (how long it stays in your system)
What the pharmacy pays
~$0.74 for 30 — not your price
FDA application
ANDA076249
Availability
Discontinued (per FDA)

How long does Metformin Hydrochloride stay in your body?

The elimination half-life of metformin hydrochloride is about 6.2 hours (plasma elimination half-life in adults with normal kidney function) — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Metformin is not metabolized and has no active metabolites, so 6.2 hours reflects the parent drug. The often-cited ~17.6-hour "blood" half-life reflects the drug lingering in red blood cells (distribution), not parent-drug elimination. The half-life is prolonged when kidney function is reduced.

This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: Metformin Hydrochloride Tablets, USP — DailyMed (Clinical Pharmacology / Pharmacokinetics).

Drug class

May treat (source: NIH RxClass)

Dosage forms

Solution, Tablet and Tablet, extended release

The forms currently marketed in the U.S., per the FDA National Drug Code Directory.

Ways to save

Ask for the generic

Same active ingredient, far cheaper. Is there a generic? →

Request a 90-day supply

Bulk fills usually lower the per-dose price vs monthly refills.

Use copay cards

Manufacturer copay cards & patient-assistance programs — especially for brand drugs.

Compare alternatives

A same-class option may cost less. See alternatives →

Frequently asked questions

What does Metformin Hydrochloride treat?
Metformin Hydrochloride (Metformin Hydrochloride) may be used to treat type 2 diabetes mellitus, based on NIH RxClass drug-classification data (conditions a drug may treat — not a verbatim copy of the FDA-approved label). This is general reference, not medical advice.
How is Metformin Hydrochloride rated?
pharmaranks gives Metformin Hydrochloride a composite score of 3.6 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
How much does Metformin Hydrochloride cost?
Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.74 for 30, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
Is there a coupon or discount for Metformin Hydrochloride?
pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Metformin Hydrochloride. To pay less, Metformin Hydrochloride is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
Who makes Metformin Hydrochloride?
Metformin Hydrochloride is marketed by Granules. You can see Granules's full profile, rating, and other products on pharmaranks.
Is Metformin Hydrochloride a brand-name or generic drug?
Metformin Hydrochloride is a generic medication; its active ingredient is Metformin Hydrochloride. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
Is Metformin Hydrochloride available over the counter?
No. Metformin Hydrochloride is a prescription (Rx) medication in the US — you need a prescription from a licensed clinician (in person or via telehealth); it isn't sold over the counter. For some conditions there are OTC alternatives — ask your pharmacist.
What forms does Metformin Hydrochloride come in?
Metformin Hydrochloride is currently marketed as solution, tablet and tablet, extended release, per the FDA's National Drug Code Directory.
What class of drug is Metformin Hydrochloride?
Metformin Hydrochloride is classified as biguanide, per the FDA's Established Pharmacologic Class.
Is Metformin Hydrochloride FDA-registered?
Metformin Hydrochloride is on record with the U.S. FDA under application number ANDA076249. You can verify this on its official FDA label.
Has Metformin Hydrochloride been recalled by the FDA?
Metformin Hydrochloride has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
Is Metformin Hydrochloride safe?
There's no single safe-or-not verdict. pharmaranks gives Metformin Hydrochloride a recall-safety score of 72/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.

Information is sourced from public FDA regulatory data. Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.

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metformin hydrochloride

72/100