INVEGA HAFYERA vs SAPHRIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 23, 2026·How we rate

Possible drug interaction. INVEGA HAFYERA and SAPHRIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INVEGA HAFYERA	SAPHRIS
Rating	70/100	70/100
Pharmacy pays	—	~$73.98 /30
Type	RX	RX
Active ingredient	PALIPERIDONE PALMITATE	ASENAPINE MALEATE
Manufacturer	Janssen Pharms	Abbvie
Dosage forms	Injectable	Tablet
Drug class	Atypical Antipsychotic	Atypical Antipsychotic
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 24 hours (terminal/elimination half-life)
Treats	Bipolar Disorder, Depressive Disorder, Schizophrenia	Bipolar Disorder, Schizophrenia

invega hafyera saphris

Rating

70/100

Pharmacy pays

—

~$73.98 /30

Type

Active ingredient

PALIPERIDONE PALMITATE

ASENAPINE MALEATE

Manufacturer

Janssen Pharms

Abbvie

Dosage forms

Injectable

Tablet

Drug class

Atypical Antipsychotic

Boxed warning

Half-life

—

about 24 hours (terminal/elimination half-life)

Treats

Bipolar Disorder, Depressive Disorder, Schizophrenia

Bipolar Disorder, Schizophrenia

Frequently asked questions

Which is better-rated, Invega Hafyera or Saphris?

Invega Hafyera and Saphris are tied at 3.5 out of 5 by our independent rating.

What is the difference between Invega Hafyera and Saphris?

Invega Hafyera contains Paliperidone Palmitate, while Saphris contains Asenapine Maleate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.