INDOMETHACIN vs VOLTAREN-XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 17, 2026·How we rate

Possible drug interaction. INDOMETHACIN and VOLTAREN-XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INDOMETHACIN	VOLTAREN-XR
Rating	72/100	70/100
Pharmacy pays	~$4.06 /30	$0.36 /mL
Type	RX	RX
Active ingredient	INDOMETHACIN	DICLOFENAC SODIUM
Manufacturer	Rising	Novartis
Dosage forms	Capsule, Capsule, extended release, Suppository	Tablet, extended release
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 4.5 hours	about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus	Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

indomethacin voltaren-xr

Rating

72/100

70/100

Pharmacy pays

~$4.06 /30

$0.36 /mL

Type

Active ingredient

INDOMETHACIN

DICLOFENAC SODIUM

Manufacturer

Rising

Novartis

Dosage forms

Capsule, Capsule, extended release, Suppository

Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 4.5 hours

about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

Which is better-rated, Indomethacin or Voltaren-XR?

By our independent rating, Indomethacin scores higher — 3.6 vs 3.5 out of 5 for Voltaren-XR. Ratings are based on FDA regulatory (recall-safety) data.

What is the difference between Indomethacin and Voltaren-XR?

Indomethacin contains Indomethacin, while Voltaren-XR contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.