INDOMETHACIN vs PIROXICAM

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 16, 2026·How we rate

Possible drug interaction. INDOMETHACIN and PIROXICAM are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INDOMETHACIN	PIROXICAM
Rating	72/100	72/100
Pharmacy pays	~$4.06 /30	~$5.35 /30
Type	RX	RX
Active ingredient	INDOMETHACIN	PIROXICAM
Manufacturer	Rising	Unichem
Dosage forms	Capsule, Capsule, extended release, Suppository	Capsule
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	Boxed warning
Half-life	about 4.5 hours	—
Treats	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus	Rheumatoid Arthritis, Inflammation, Osteoarthritis

indomethacin piroxicam

Rating

72/100

Pharmacy pays

~$4.06 /30

~$5.35 /30

Type

Active ingredient

INDOMETHACIN

PIROXICAM

Manufacturer

Rising

Unichem

Dosage forms

Capsule, Capsule, extended release, Suppository

Capsule

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Boxed warning

Half-life

about 4.5 hours

—

Treats

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Rheumatoid Arthritis, Inflammation, Osteoarthritis

Frequently asked questions

Which is better-rated, Indomethacin or Piroxicam?

Indomethacin and Piroxicam are tied at 3.6 out of 5 by our independent rating.

Which is cheaper, Indomethacin or Piroxicam?

Indomethacin costs pharmacies less to acquire — about $4.06 vs $5.35 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Indomethacin and Piroxicam?

Indomethacin contains Indomethacin, while Piroxicam contains Piroxicam — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.