INDOMETHACIN vs PENNSAID
Independent side-by-side comparison.
Possible drug interaction. INDOMETHACIN and PENNSAID are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.
Rating
72/100
New
Pharmacy pays
~$4.06 /30
$0.36 /mL
Type
RX
RX
Active ingredient
INDOMETHACIN
DICLOFENAC SODIUM
Dosage forms
Capsule, Capsule, extended release, Suppository
Solution
Drug class
Nonsteroidal Anti-Inflammatory Drug
Nonsteroidal Anti-Inflammatory Drug
Boxed warning
None
None
Half-life
about 4.5 hours
about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)
Treats
Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus
Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea
Frequently asked questions
What is the difference between Indomethacin and Pennsaid?
Indomethacin contains Indomethacin, while Pennsaid contains Diclofenac Sodium — they have different active ingredients.
Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.