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INDOCIN vs VOLTAREN-XR

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 11, 2026·How we rate

Possible drug interaction. INDOCIN and VOLTAREN-XR are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Rating

New
70/100

Pharmacy pays

~$4.06 /30
$0.36 /mL

Type

RX
RX

Active ingredient

INDOMETHACIN
DICLOFENAC SODIUM

Dosage forms

Suppository
Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug
Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None
None

Half-life

about 4.5 hours
about 2 hours (terminal/elimination half-life; the label's table gives a mean of 2.3 hours in healthy adults, with wide variation between people — 48% coefficient of variation)

Treats

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus
Juvenile Arthritis, Rheumatoid Arthritis, Dysmenorrhea

Frequently asked questions

What is the difference between Indocin and Voltaren-XR?

Indocin contains Indomethacin, while Voltaren-XR contains Diclofenac Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.