INDOCIN vs NAPROXEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 12, 2026·How we rate

Possible drug interaction. INDOCIN and NAPROXEN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INDOCIN	NAPROXEN
Rating	New	72/100
Pharmacy pays	~$4.06 /30	$0.06 /mL
Type	RX	RX
Active ingredient	INDOMETHACIN	NAPROXEN
Manufacturer	Zyla Life Sciences	Hikma
Dosage forms	Suppository	Tablet
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	Boxed warning
Half-life	about 4.5 hours	about 12 to 17 hours
Treats	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus	Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

indocin naproxen

Rating

New

72/100

Pharmacy pays

~$4.06 /30

$0.06 /mL

Type

Active ingredient

INDOMETHACIN

NAPROXEN

Manufacturer

Zyla Life Sciences

Hikma

Dosage forms

Suppository

Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Boxed warning

Half-life

about 4.5 hours

about 12 to 17 hours

Treats

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

Frequently asked questions

What is the difference between Indocin and Naproxen?

Indocin contains Indomethacin, while Naproxen contains Naproxen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.