INDOCIN vs NAPRELAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated October 7, 2026·How we rate

Possible drug interaction. INDOCIN and NAPRELAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INDOCIN	NAPRELAN
Rating	70/100	New
Pharmacy pays	~$4.06 /30	$0.06 /mL
Type	RX	RX
Active ingredient	INDOMETHACIN	NAPROXEN SODIUM
Manufacturer	Zyla Life Sciences	Twi Pharms
Dosage forms	Suppository	Tablet, extended release
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	Boxed warning
Half-life	about 4.5 hours	about 12 to 17 hours
Treats	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus	Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

indocin naprelan

Rating

70/100

New

Pharmacy pays

~$4.06 /30

$0.06 /mL

Type

Active ingredient

INDOMETHACIN

NAPROXEN SODIUM

Manufacturer

Zyla Life Sciences

Twi Pharms

Dosage forms

Suppository

Tablet, extended release

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Boxed warning

Half-life

about 4.5 hours

about 12 to 17 hours

Treats

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Juvenile Arthritis, Rheumatoid Arthritis, Back Pain

Frequently asked questions

What is the difference between Indocin and Naprelan?

Indocin contains Indomethacin, while Naprelan contains Naproxen Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.