INDOCIN vs MOTRIN MIGRAINE PAIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Possible drug interaction. INDOCIN and MOTRIN MIGRAINE PAIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	INDOCIN	MOTRIN MIGRAINE PAIN
Rating	New	70/100
Pharmacy pays	~$4.06 /30	$0.04 /mL
Type	RX	RX
Active ingredient	INDOMETHACIN	IBUPROFEN
Manufacturer	Zyla Life Sciences	Kenvue Brands
Dosage forms	Suppository	Tablet
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 4.5 hours	about 1.8 to 2.0 hours
Treats	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus	Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

indocin motrin migraine pain

Rating

New

70/100

Pharmacy pays

~$4.06 /30

$0.04 /mL

Type

Active ingredient

INDOMETHACIN

IBUPROFEN

Manufacturer

Zyla Life Sciences

Kenvue Brands

Dosage forms

Suppository

Tablet

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 4.5 hours

about 1.8 to 2.0 hours

Treats

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Juvenile Arthritis, Rheumatoid Arthritis, Bursitis

Frequently asked questions

What is the difference between Indocin and Motrin Migraine Pain?

Indocin contains Indomethacin, while Motrin Migraine Pain contains Ibuprofen — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.