HYDROXYZINE HYDROCHLORIDE vs HYDROXYZINE PAMOATE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 20, 2026·How we rate

Possible drug interaction. HYDROXYZINE HYDROCHLORIDE and HYDROXYZINE PAMOATE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	HYDROXYZINE HYDROCHLORIDE	HYDROXYZINE PAMOATE
Rating	New	70/100
Pharmacy pays	$0.04 /mL	—
Type	RX	RX
Active ingredient	HYDROXYZINE HYDROCHLORIDE	HYDROXYZINE PAMOATE
Manufacturer	Pliva	Watson Labs
Dosage forms	Injectable, Solution, Syrup, Tablet	Capsule
Drug class	Antihistamine	Antihistamine
Boxed warning	None	None
Half-life	about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)	about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)
Treats	Anxiety Disorders, Nausea, Pruritus	Anxiety Disorders, Nausea, Pruritus

hydroxyzine hydrochloride hydroxyzine pamoate

Rating

New

70/100

Pharmacy pays

$0.04 /mL

—

Type

Active ingredient

HYDROXYZINE HYDROCHLORIDE

HYDROXYZINE PAMOATE

Manufacturer

Pliva

Watson Labs

Dosage forms

Injectable, Solution, Syrup, Tablet

Capsule

Drug class

Antihistamine

Boxed warning

None

Half-life

about 14 to 20 hours in healthy adults (two reported mean values: 20.0 ± 4.1 hours and 14.0 hours)

Treats

Anxiety Disorders, Nausea, Pruritus

Frequently asked questions

What is the difference between Hydroxyzine Hydrochloride and Hydroxyzine Pamoate?

Hydroxyzine Hydrochloride contains Hydroxyzine Hydrochloride, while Hydroxyzine Pamoate contains Hydroxyzine Pamoate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.