GRALISE vs ZONEGRAN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. GRALISE and ZONEGRAN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	GRALISE	ZONEGRAN
Rating	New	New
Pharmacy pays	~$1.22 /30	~$3.16 /30
Type	RX	RX
Active ingredient	GABAPENTIN	ZONISAMIDE
Manufacturer	Almatica	Advanz Pharma
Dosage forms	Tablet	Capsule
Drug class	Anti-Epileptic Agent	Anti-Epileptic Agent
Boxed warning	None	None
Half-life	about 5 to 7 hours in adults with normal kidney function	—
Treats	Bipolar Disorder, Partial Epilepsies, Phobic Disorders	Partial Epilepsies

gralise zonegran

Rating

New

Pharmacy pays

~$1.22 /30

~$3.16 /30

Type

Active ingredient

GABAPENTIN

ZONISAMIDE

Manufacturer

Almatica

Advanz Pharma

Dosage forms

Tablet

Capsule

Drug class

Anti-Epileptic Agent

Boxed warning

None

Half-life

about 5 to 7 hours in adults with normal kidney function

—

Treats

Bipolar Disorder, Partial Epilepsies, Phobic Disorders

Partial Epilepsies

Frequently asked questions

Which is cheaper, Gralise or Zonegran?

Gralise costs pharmacies less to acquire — about $1.22 vs $3.16 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Gralise and Zonegran?

Gralise contains Gabapentin, while Zonegran contains Zonisamide — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.