FOCALIN XR vs QUILLICHEW ER

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Possible drug interaction. FOCALIN XR and QUILLICHEW ER are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FOCALIN XR	QUILLICHEW ER
Rating	68/100	New
Pharmacy pays	~$46.03 /30	~$18.94 /30
Type	RX	RX
Active ingredient	DEXMETHYLPHENIDATE HYDROCHLORIDE	METHYLPHENIDATE HYDROCHLORIDE
Manufacturer	Sandoz	Nextwave
Dosage forms	Capsule, extended release	Tablet, chewable, extended release
Drug class	Central Nervous System Stimulant	Central Nervous System Stimulant
Boxed warning	Boxed warning	Boxed warning
Half-life	—	about 2.7 hours
Treats	Attention Deficit Disorder with Hyperactivity	Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

focalin xr quillichew er

Rating

68/100

New

Pharmacy pays

~$46.03 /30

~$18.94 /30

Type

Active ingredient

DEXMETHYLPHENIDATE HYDROCHLORIDE

METHYLPHENIDATE HYDROCHLORIDE

Manufacturer

Sandoz

Nextwave

Dosage forms

Capsule, extended release

Tablet, chewable, extended release

Drug class

Central Nervous System Stimulant

Boxed warning

Half-life

—

about 2.7 hours

Treats

Attention Deficit Disorder with Hyperactivity

Attention Deficit Disorder with Hyperactivity, Depressive Disorder, Narcolepsy

Frequently asked questions

Which is cheaper, Focalin XR or Quillichew ER?

Quillichew ER costs pharmacies less to acquire — about $18.94 vs $46.03 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Focalin XR and Quillichew ER?

Focalin XR contains Dexmethylphenidate Hydrochloride, while Quillichew ER contains Methylphenidate Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.