FLEXERIL vs SKELAXIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. FLEXERIL and SKELAXIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FLEXERIL	SKELAXIN
Rating	New	New
Pharmacy pays	~$0.63 /30	~$11.97 /30
Type	RX	RX
Active ingredient	CYCLOBENZAPRINE HYDROCHLORIDE	METAXALONE
Manufacturer	Janssen Res and Dev	King Pharms LLC
Dosage forms	Tablet	Tablet
Drug class	Muscle Relaxant	Muscle Relaxant
Boxed warning	None	None
Half-life	about 18 hours (range roughly 8 to 37 hours) for the standard immediate-release tablet in typical adults	about 9 hours (terminal half-life 9.0 ± 4.8 hours after a 400 mg oral dose, fasted; ~8 hours at 800 mg)
Treats	Muscle Cramp, Muscle Rigidity, Muscle Spasticity	Muscle Cramp, Muscle Rigidity, Muscle Spasticity

flexeril skelaxin

Rating

New

Pharmacy pays

~$0.63 /30

~$11.97 /30

Type

Active ingredient

CYCLOBENZAPRINE HYDROCHLORIDE

METAXALONE

Manufacturer

Janssen Res and Dev

King Pharms LLC

Dosage forms

Tablet

Drug class

Muscle Relaxant

Boxed warning

None

Half-life

about 18 hours (range roughly 8 to 37 hours) for the standard immediate-release tablet in typical adults

about 9 hours (terminal half-life 9.0 ± 4.8 hours after a 400 mg oral dose, fasted; ~8 hours at 800 mg)

Treats

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Frequently asked questions

Which is cheaper, Flexeril or Skelaxin?

Flexeril costs pharmacies less to acquire — about $0.63 vs $11.97 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Flexeril and Skelaxin?

Flexeril contains Cyclobenzaprine Hydrochloride, while Skelaxin contains Metaxalone — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.