FLEXERIL vs NORFLEX

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. FLEXERIL and NORFLEX are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	FLEXERIL	NORFLEX
Rating	New	New
Pharmacy pays	~$0.63 /30	$0.48 /mL
Type	RX	RX
Active ingredient	CYCLOBENZAPRINE HYDROCHLORIDE	ORPHENADRINE CITRATE
Manufacturer	Janssen Res and Dev	Bausch
Dosage forms	Tablet	Tablet, extended release, Injectable
Drug class	Muscle Relaxant	Muscle Relaxant
Boxed warning	None	None
Half-life	about 18 hours (range roughly 8 to 37 hours) for the standard immediate-release tablet in typical adults	—
Treats	Muscle Cramp, Muscle Rigidity, Muscle Spasticity	Muscle Cramp, Muscle Rigidity, Myositis

flexeril norflex

Rating

New

Pharmacy pays

~$0.63 /30

$0.48 /mL

Type

Active ingredient

CYCLOBENZAPRINE HYDROCHLORIDE

ORPHENADRINE CITRATE

Manufacturer

Janssen Res and Dev

Bausch

Dosage forms

Tablet

Tablet, extended release, Injectable

Drug class

Muscle Relaxant

Boxed warning

None

Half-life

about 18 hours (range roughly 8 to 37 hours) for the standard immediate-release tablet in typical adults

—

Treats

Muscle Cramp, Muscle Rigidity, Muscle Spasticity

Muscle Cramp, Muscle Rigidity, Myositis

Frequently asked questions

What is the difference between Flexeril and Norflex?

Flexeril contains Cyclobenzaprine Hydrochloride, while Norflex contains Orphenadrine Citrate — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.