ACETAMINOPHEN, ASPIRIN AND CAFFEINE vs EXCEDRIN (MIGRAINE RELIEF)

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 22, 2026·How we rate

Attribute	ACETAMINOPHEN, ASPIRIN AND CAFFEINE	EXCEDRIN (MIGRAINE RELIEF)
Rating	64/100	72/100
Pharmacy pays	$0.03 /mL	$0.03 /mL
Type	OTC	OTC
Active ingredient	ACETAMINOPHEN AND ASPIRIN AND CAFFEINE	ACETAMINOPHEN AND ASPIRIN AND CAFFEINE
Manufacturer	Perrigo	Haleon US Holdings
Dosage forms	Tablet	Tablet
Drug class	—	—
Boxed warning	None	None
Half-life	about 20 minutes (the label also states 0.33 hours) for aspirin itself	about 20 minutes (the label also states 0.33 hours) for aspirin itself

acetaminophen, aspirin and caffeine excedrin (migraine relief)

Rating

64/100

72/100

Pharmacy pays

$0.03 /mL

Type

OTC

Active ingredient

ACETAMINOPHEN AND ASPIRIN AND CAFFEINE

Manufacturer

Perrigo

Haleon US Holdings

Dosage forms

Tablet

Drug class

—

Boxed warning

None

Half-life

about 20 minutes (the label also states 0.33 hours) for aspirin itself

Get excedrin (migraine relief)higher-rated option

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Where to buy

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Frequently asked questions

Which is better-rated, Acetaminophen, Aspirin and Caffeine or Excedrin (Migraine Relief)?

By our independent rating, Excedrin (Migraine Relief) scores higher — 3.6 vs 3.2 out of 5 for Acetaminophen, Aspirin and Caffeine. Ratings are based on FDA regulatory (recall-safety) data.

Which is cheaper, Acetaminophen, Aspirin and Caffeine or Excedrin (Migraine Relief)?

Pharmacies pay about the same to acquire either one — roughly $0.03 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Acetaminophen, Aspirin and Caffeine and Excedrin (Migraine Relief)?

Both Acetaminophen, Aspirin and Caffeine and Excedrin (Migraine Relief) share the active ingredient Acetaminophen and Aspirin and Caffeine.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.