acetaminophen, aspirin and caffeine
Pharmaranks rates Acetaminophen, Aspirin and Caffeine 3.2/5 for recall safety — an independent score from its FDA recall history and its manufacturer's record. Acetaminophen, Aspirin and Caffeine is a combination medicine containing Acetaminophen, Aspirin, and Caffeine.
Acetaminophen and Aspirin and Caffeine · by Perrigo
Generic of Excedrin (Migraine Relief)
Based on 1 source · Recall-safety score from FDA recall history — this product's own recalls and its manufacturer's record. Not an efficacy or quality rating. methodology →
Key facts
- Active ingredient
- Acetaminophen and Aspirin and Caffeine
- Form
- Tablet
- Strength
- Acetaminophen 250MG; Aspirin 250MG; Caffeine 65MG
- Type
- Over-the-counter (OTC)
- Brand or generic
- Generic
- Manufacturer
- Perrigo
- Half-life
- about 20 minutes (the label also states 0.33 hours) for aspirin itself (how long it stays in your system)
- What the pharmacy pays
- ~$0.03 per ml — not your price
- FDA application
- ANDA075794
What is Acetaminophen, Aspirin and Caffeine?
From the FDA label:Use • treats migraine
How to use
Directions • do not use more than directed • adults: take 2 caplets with a glass of water • if symptoms persist or worsen, ask your doctor • do not take more than 2 caplets in 24 hours, unless directed by a doctor • under 18 years of age: ask a doctor
Warnings
Important safety information
Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: • skin reddening • blisters • rash If a skin reaction occurs, stop use and seek medical help right away. Allergy alert: Aspirin may cause a severe allergic reaction which may include: • hives • facial swelling • asthma (wheezing) • shock Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take • more than 2 caplets in 24 hours, which is the maximum daily amount • with other drugs containing acetaminophen • 3 or more alcoholic drinks every day while using this product Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you • are age 60 or older • have had stomach ulcers or bleeding problems • take a blood thinning (anticoagulant) or steroid drug • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) • have 3 or more alcoholic drinks every day while using this product • take more or for a longer time than directed Medication overuse headache warning: Headaches may worsen if this product is used for 10 or more days per month. Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat. Do not use • if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist Ask a doctor before use if • you have never had migraines diagnosed by a health professional • you have a headache that is different from your usual migraines • you have the worst headache of your life • you have fever and stiff neck • you have headaches beginning after or caused by head injury, exertion, coughing or bending • you experienced your first headache after the age of 50 • you have daily headaches • you have a migraine so severe as to require bed rest • you have liver disease • stomach bleeding warning applies to you • you have a history of stomach problems, such as heartburn • you have high blood pressure, heart disease, liver cirrhosis, or kidney disease • you are taking a diuretic • you have asthma • you have problems or serious side effects from taking pain relievers or fever reducers • you have vomiting with your migraine headache Ask a doctor or pharmacist before use if you are • taking a prescription drug for: • diabetes • gout • arthritis • under a doctor’s care for any serious condition • taking any other drug • taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer Stop use and ask a doctor if • an allergic reaction occurs. Seek medical help right away. • you experience any of the following signs of stomach bleeding: • feel faint • vomit blood • have bloody or black stools • have stomach pain that does not get better • your migraine is not relieved or worsens after first dose • new or unexpected symptoms occur • ringing in the ears or loss of hearing occurs If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
How long does Acetaminophen and Aspirin and Caffeine stay in your body?
The elimination half-life of acetaminophen and aspirin and caffeine is about 20 minutes (the label also states 0.33 hours) for aspirin itself — the time it takes the body to clear about half of it. As a rule of thumb, a medicine is mostly gone after roughly 4 to 5 half-lives, though this varies from person to person with age and kidney or liver function. Aspirin's own half-life is misleadingly short: the label says aspirin "is rapidly hydrolyzed in plasma to salicylic acid, with a half-life of 20 minutes," so aspirin behaves essentially as a prodrug and salicylic acid is the active moiety that persists. The label gives salicylic acid a half-life of 1.71 hours at these doses, "correspond[ing] well with data from the literature at lower doses which state a resultant half-life of approximately 2 to 3 hours." Salicylate elimination is saturable: "at higher doses, the elimination of salicylic acid follows zero-order kinetics... with an apparent half-life of 6 hours or higher," and "following toxic doses (10 to 20 g), the plasma half-life may be increased to over 20 hours." Renal clearance of free salicylate is urine-pH dependent (rising from <5% to >80% as urinary pH goes above 6.5). This label does not quantify a half-life change by age; for organ impairment it does not give altered half-life numbers but instructs that aspirin be avoided in severe renal failure (GFR <10 mL/min) and in severe hepatic insufficiency. Note also that aspirin's antiplatelet effect far outlasts both half-lives, because it irreversibly acetylates platelet COX-1 for the platelet's lifespan — half-life does not predict duration of effect here. Half-life figures are pharmacokinetic, not a drug-test detection window and not dosing guidance.
This is general information, not medical advice. It doesn’t tell you when a drug test would read negative (tests detect substances for different, often longer, windows) or when it’s safe to take another dose — ask your pharmacist or prescriber. Source: DailyMed — ASPIRIN AND EXTENDED-RELEASE DIPYRIDAMOLE capsule, extended release (Clinical Pharmacology / Pharmacokinetics: Aspirin).
Dosage forms
Tablet
The forms currently marketed in the U.S., per the FDA National Drug Code Directory.
Ways to save
Ask for the generic
Same active ingredient, far cheaper. Is there a generic? →
Request a 90-day supply
Bulk fills usually lower the per-dose price vs monthly refills.
Use copay cards
Manufacturer copay cards & patient-assistance programs — especially for brand drugs.
Compare alternatives
A same-class option may cost less. See alternatives →
Frequently asked questions
- How is Acetaminophen, Aspirin and Caffeine rated?
- pharmaranks gives Acetaminophen, Aspirin and Caffeine a composite score of 3.2 out of 5, currently based on 1 weighted source (FDA regulatory recall-safety data weighted highest). See our methodology at /how-we-rate.
- How much does Acetaminophen, Aspirin and Caffeine cost?
- Nobody can tell you what you will pay — your price is set by your insurer's formulary, your deductible and the pharmacy's markup, and none of those are published. What IS published is what the pharmacy paid to acquire it: about $0.03 per ml, per the CMS NADAC survey. Treat that as the floor, not the quote — ask the pharmacist for the cash price as well as your copay, because for cheap generics the cash price often wins.
- Is there a coupon or discount for Acetaminophen, Aspirin and Caffeine?
- pharmaranks is an independent ratings site, not a pharmacy — we don't issue coupons or sell Acetaminophen, Aspirin and Caffeine. To pay less, Acetaminophen, Aspirin and Caffeine is already a generic — usually the lowest-cost version — so the main levers are comparing cash prices between pharmacies and using a pharmacy discount-card service. Prices vary by pharmacy, insurance, and location, so always confirm at the counter. This is general reference, not medical or financial advice.
- Who makes Acetaminophen, Aspirin and Caffeine?
- Acetaminophen, Aspirin and Caffeine is marketed by Perrigo. You can see Perrigo's full profile, rating, and other products on pharmaranks.
- Is Acetaminophen, Aspirin and Caffeine a brand-name or generic drug?
- Acetaminophen, Aspirin and Caffeine is a generic medication; its active ingredient is Acetaminophen and Aspirin and Caffeine. Generics contain the same active ingredient as the brand-name original and are usually lower cost.
- Is Acetaminophen, Aspirin and Caffeine available over the counter?
- Yes. Acetaminophen, Aspirin and Caffeine is an over-the-counter (OTC) product — you can buy it without a prescription. Follow the label directions and ask a pharmacist if you're unsure whether it's right for you.
- What forms does Acetaminophen, Aspirin and Caffeine come in?
- Acetaminophen, Aspirin and Caffeine is currently marketed as tablet, per the FDA's National Drug Code Directory.
- Is Acetaminophen, Aspirin and Caffeine FDA-registered?
- Acetaminophen, Aspirin and Caffeine is on record with the U.S. FDA under application number ANDA075794. You can verify this on its official FDA label.
- Has Acetaminophen, Aspirin and Caffeine been recalled by the FDA?
- Acetaminophen, Aspirin and Caffeine has no FDA recalls recorded under its own application in the openFDA enforcement database. Its recall-safety score reflects its manufacturer's overall recall record. This is general reference, not medical advice — check the FDA recall database for the latest alerts.
- Is Acetaminophen, Aspirin and Caffeine safe?
- There's no single safe-or-not verdict. pharmaranks gives Acetaminophen, Aspirin and Caffeine a recall-safety score of 64/100, based on its FDA recall history (no recalls under its own FDA application) — not an efficacy or side-effect rating. Review its FDA-label side effects and warnings before use, and always consult a licensed professional.
Clinical content sourced from the FDA label via openFDA (U.S. FDA). View the FDA label on DailyMed → Provided for general reference only — not medical advice. Always consult a licensed professional and the current prescribing information.
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acetaminophen, aspirin and caffeine
64/100