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EXALGO vs PALLADONE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 19, 2026·How we rate

Rating

70/100
New

Pharmacy pays

$0.57 /mL
$0.57 /mL

Type

RX
RX

Active ingredient

HYDROMORPHONE HYDROCHLORIDE
HYDROMORPHONE HYDROCHLORIDE

Dosage forms

Tablet, extended release
Capsule, extended release

Drug class

Opioid Agonist
Opioid Agonist

Boxed warning

None
None

Half-life

about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid
about 2.3 hours (terminal elimination half-life after an intravenous dose); after an oral dose the label reports a mean T½ of about 2.6 hours for the 8 mg tablet and 2.8 hours for the oral liquid

Treats

Cough, Postoperative Pain
Cough, Postoperative Pain

Frequently asked questions

Which is cheaper, Exalgo or Palladone?

Pharmacies pay about the same to acquire either one — roughly $0.57 per ml, per the CMS NADAC survey. That is not what you will be charged: your price is set by your insurer and the pharmacy, not by what the drug cost them.

What is the difference between Exalgo and Palladone?

Both Exalgo and Palladone share the active ingredient Hydromorphone Hydrochloride.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.