EVOMELA vs YONDELIS

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. EVOMELA and YONDELIS are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EVOMELA	YONDELIS
Rating	New	New
Pharmacy pays	—	—
Type	RX	RX
Active ingredient	MELPHALAN HYDROCHLORIDE	TRABECTEDIN
Manufacturer	Acrotech Biopharma	Janssen Prods
Dosage forms	Injectable	Injectable
Drug class	Alkylating Drug	Alkylating Drug
Boxed warning	Boxed warning	None
Treats	Breast Neoplasms, Multiple Myeloma, Neuroblastoma	Leiomyosarcoma, Liposarcoma

evomela yondelis

Rating

New

Pharmacy pays

—

Type

Active ingredient

MELPHALAN HYDROCHLORIDE

TRABECTEDIN

Manufacturer

Acrotech Biopharma

Janssen Prods

Dosage forms

Injectable

Drug class

Alkylating Drug

Boxed warning

None

Treats

Breast Neoplasms, Multiple Myeloma, Neuroblastoma

Leiomyosarcoma, Liposarcoma

Frequently asked questions

What is the difference between Evomela and Yondelis?

Evomela contains Melphalan Hydrochloride, while Yondelis contains Trabectedin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.