ETODOLAC vs INDOMETHACIN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated August 21, 2026·How we rate

Possible drug interaction. ETODOLAC and INDOMETHACIN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	ETODOLAC	INDOMETHACIN
Rating	New	72/100
Pharmacy pays	~$22.58 /30	~$4.06 /30
Type	RX	RX
Active ingredient	ETODOLAC	INDOMETHACIN
Manufacturer	Ivax Sub Teva Pharms	Rising
Dosage forms	Capsule, Tablet, Tablet, extended release	Capsule, Capsule, extended release, Suppository
Drug class	Nonsteroidal Anti-Inflammatory Drug	Nonsteroidal Anti-Inflammatory Drug
Boxed warning	None	None
Half-life	about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)	about 4.5 hours
Treats	Rheumatoid Arthritis, Osteoarthritis, Pain	Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

etodolac indomethacin

Rating

New

72/100

Pharmacy pays

~$22.58 /30

~$4.06 /30

Type

Active ingredient

ETODOLAC

INDOMETHACIN

Manufacturer

Ivax Sub Teva Pharms

Rising

Dosage forms

Capsule, Tablet, Tablet, extended release

Capsule, Capsule, extended release, Suppository

Drug class

Nonsteroidal Anti-Inflammatory Drug

Boxed warning

None

Half-life

about 6.4 hours (roughly 6 to 8 hours; label reports a mean terminal half-life of 6.4 hours with 22% coefficient of variation)

about 4.5 hours

Treats

Rheumatoid Arthritis, Osteoarthritis, Pain

Rheumatoid Arthritis, Bursitis, Patent Ductus Arteriosus

Frequently asked questions

Which is cheaper, Etodolac or Indomethacin?

Indomethacin costs pharmacies less to acquire — about $4.06 vs $22.58 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Etodolac and Indomethacin?

Etodolac contains Etodolac, while Indomethacin contains Indomethacin — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.