EFFEXOR XR vs MILNACIPRAN HYDROCHLORIDE

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. EFFEXOR XR and MILNACIPRAN HYDROCHLORIDE are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	EFFEXOR XR	MILNACIPRAN HYDROCHLORIDE
Rating	New	New
Pharmacy pays	~$3.59 /30	~$97.10 /30
Type	RX	RX
Active ingredient	VENLAFAXINE HYDROCHLORIDE	MILNACIPRAN HYDROCHLORIDE
Manufacturer	Upjohn	Hetero Labs Ltd V
Dosage forms	Capsule, extended release	Tablet, Kit
Drug class	Serotonin and Norepinephrine Reuptake Inhibitor	Serotonin and Norepinephrine Reuptake Inhibitor
Boxed warning	Boxed warning	Boxed warning
Half-life	about 5 hours (mean roughly 5 ± 2 hours) for the parent drug venlafaxine in adults with normal organ function	—
Treats	Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Depressive Disorder	Major Depressive Disorder

effexor xr milnacipran hydrochloride

Rating

New

Pharmacy pays

~$3.59 /30

~$97.10 /30

Type

Active ingredient

VENLAFAXINE HYDROCHLORIDE

MILNACIPRAN HYDROCHLORIDE

Manufacturer

Upjohn

Hetero Labs Ltd V

Dosage forms

Capsule, extended release

Tablet, Kit

Drug class

Serotonin and Norepinephrine Reuptake Inhibitor

Boxed warning

Half-life

about 5 hours (mean roughly 5 ± 2 hours) for the parent drug venlafaxine in adults with normal organ function

—

Treats

Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Depressive Disorder

Major Depressive Disorder

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Frequently asked questions

Which is cheaper, Effexor XR or Milnacipran Hydrochloride?

Effexor XR costs pharmacies less to acquire — about $3.59 vs $97.10 for a 30-count supply, per the CMS NADAC survey. That gap is in the pharmacy's cost of goods, not necessarily in what you pay: your price is set afterwards by your insurer and the pharmacy.

What is the difference between Effexor XR and Milnacipran Hydrochloride?

Effexor XR contains Venlafaxine Hydrochloride, while Milnacipran Hydrochloride contains Milnacipran Hydrochloride — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.