DYNAPEN vs UNIPEN

Independent side-by-side comparison.

Rated against independent regulatory sources·Last updated June 7, 2026·How we rate

Possible drug interaction. DYNAPEN and UNIPEN are different prescription medicines. Combining or switching between them can cause interactions — talk to a pharmacist or prescriber before making changes. This page is not medical advice.

Attribute	DYNAPEN	UNIPEN
Rating	New	New
Pharmacy pays	~$23.75 /30	—
Type	RX	RX
Active ingredient	DICLOXACILLIN SODIUM	NAFCILLIN SODIUM
Manufacturer	Apothecon	Wyeth Ayerst
Dosage forms	—	Injectable
Drug class	Penicillin-Class Antibacterial	Penicillin-Class Antibacterial
Boxed warning	None	None
Treats	Cellulitis, Osteomyelitis, Postoperative Complications	Cellulitis, Bacterial Endocarditis, Osteomyelitis

dynapen unipen

Rating

New

Pharmacy pays

~$23.75 /30

—

Type

Active ingredient

DICLOXACILLIN SODIUM

NAFCILLIN SODIUM

Manufacturer

Apothecon

Wyeth Ayerst

Dosage forms

—

Injectable

Drug class

Penicillin-Class Antibacterial

Boxed warning

None

Treats

Cellulitis, Osteomyelitis, Postoperative Complications

Cellulitis, Bacterial Endocarditis, Osteomyelitis

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Frequently asked questions

What is the difference between Dynapen and Unipen?

Dynapen contains Dicloxacillin Sodium, while Unipen contains Nafcillin Sodium — they have different active ingredients.

Ratings are based on FDA regulatory (recall-safety) data. This comparison is for general reference only — not medical advice. Always consult a licensed professional before choosing or switching a medication.